The study is devoted to the problem of assessing the relationship between financial and economic factors and the level of suicides in the Russian regions. We used panel data for 80 regions of Russia for the period 2005 (2010)–2020. We applied the Driscoll-Kraay standard error fixed effects method to solve cross-section dependence of data. The results showed that the volume of household debt on loans and the level of debt burden reduces the suicide rate in the regions. We found a U-shaped relationship between the overdue debt and the number of suicides in the general population, as well as in rural and urban populations. Consequently, the initial increase in overdue debt reduces the number of suicides, and its further increase leads to an increase in mortality. We also determined the extreme points of overdue debt for the entire population, as well as urban and rural. It has been established that the analyzed factors have a greater impact on the level of suicides among the rural population.